Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors while in the central nervous system, conolidine modulates alternate molecular targets. A Science Improvements examine identified that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://rowannvzab.gynoblog.com/36632776/an-unbiased-view-of-alternative-natural-pain-relief-to-replace-traditional-painkillers