There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to decrease afferent discomfort transmission and deliver analgesia. For that reason, medications like clonidine that concentrate on alpha-2 receptors can affect the transmission of pain. Clonidine is dispersed in https://www.proleviate.com/post/the-new-pain-killer-conolidine