CRISPR-Cas is a powerful genome editing technology and has a great potential for in vivo gene therapy. Successful translational application of CRISPR-Cas to biomedicine still faces many safety concerns. including off-target side effect. cell fitness problem after CRISPR-Cas treatment. https://www.markbroyard.com/super-save-whole-wheat-phyllo-pastry-sheets-jufka-sa-integralnim-brasnom-12pcs-x-450g-jami-supply-great-choice/