At an oral dose of 2000 mg/kg/day in rats, maternal toxicity and deaths were found with an increased incidence of early fetal resorption; spontaneous abortions happened in cynomolgus monkeys with the maternally toxic oral dose of 2000 mg/kg/working day; there are no adequate and very well-managed trials in pregnant women; https://edithb332oal9.losblogos.com/profile