Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals from the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, which... https://andyj778qmf4.humor-blog.com/profile