Metabolism The major pathway of thyroid hormone metabolism is through sequential deiodination. Roughly eighty% of circulating T3 is derived from peripheral T4 by monodeiodination. The liver is the foremost site of degradation for each T4 and T3. DailyMed will produce notification of updates and additions to Drug Label information at https://liothyronine-sodium88765.tribunablog.com/the-ultimate-guide-to-t3-45474718