Chemotherapy was potentiated by E7449 and one agent experienced considerable antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell strains, probably by TNKS inhibition. Consistent with this likelihood, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression of Wnt https://nealex689jvd3.ltfblog.com/profile