Effects over the Cardiovascular System Codeine creates peripheral vasodilation which may end in orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation may incorporate pruritus, flushing, crimson eyes and sweating and/or orthostatic hypotension. Promethazine with Codeine Oral Solution is not advisable to be used in pregnant women [see https://willf219hrb9.mybuzzblog.com/profile