The drug has no impact on the pharmacological effects of other anticonvulsants, and also for the performance of oral contraceptives, diuretics, oral antidiabetic brokers or insulin. Cimetidine Concomitant administration of tramadol quick-release tablets with cimetidine, a weak CPY3A4 inhibitor, would not result in clinically significant variations in tramadol pharmacokinetics. Try https://bettersleepuk.com/