The data unveiled the mRNA-loaded polyplex nanomicelle was instantly engulfed by cellular late endosome, then unfold into the cytosol homogeneously at a amount of below 20 min publish-administration with the mRNA medicine. The mRNA expression persisted for at least six-days article-injection in vivo. Additionally, the Runx1 mRNA sent by polyplex https://www.directivepublications.org/the-journal-of-molecular-biology/